Peroxisome proliferator activated receptor α
WebThe UDP-glucuronosyltransferase 1A9 Enzyme Is a Peroxisome Proliferator-activated Receptor α and γ Target Gene . × Close Log In. Log in with Facebook Log in with Google. … WebPeroxisome proliferator-activated receptors (PPARs) are a group of receptors with diverse biological functions. Natural and synthetic PPAR agonists show potential for treatment of …
Peroxisome proliferator activated receptor α
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WebNov 6, 2024 · Efficacy and Safety of Pemafibrate, a Novel Selective Peroxisome Proliferator-Activated Receptor α Modulator (SPPARMα): Pooled Analysis of Phase 2 and 3 Studies in Dyslipidemic Patients with or without Statin Combination Authors WebAbstract. The peroxisome proliferator-activated receptors (PPAR) , and are ligand-activated nuclear receptors involved in a number of physiological processes, including lipid and …
WebApr 22, 2016 · Peroxisome proliferator-activated receptors (PPARs) are a family of transcriptional factors. Among PPAR proteins, PPARα has been shown to be involved in lipid metabolism through upregulation of fatty acid oxidation [ 8 ]. Activated PPARs upregulate the expression of genes encoding enzymes involved in downstream lipid oxidation [ 9 ]. WebThe protein levels of PPAR-γ, α-smooth muscle actin (α-SMA) and type I collagen expression were evaluated by the Western blotting method. Results In vitro studies revealed that …
WebAug 3, 2024 · Sterol regulatory element binding protein (SREBP)-1c is a transcription factor that regulates lipid synthesis from glucose in the liver. It is activated by sucrose, which … Peroxisome proliferator-activated receptor alpha (PPAR-α), also known as NR1C1 (nuclear receptor subfamily 1, group C, member 1), is a nuclear receptor protein functioning as a transcription factor that in humans is encoded by the PPARA gene. Together with peroxisome proliferator-activated receptor delta … See more PPAR-α is primarily activated through ligand binding. Endogenous ligands include fatty acids such as arachidonic acid as well as other polyunsaturated fatty acids and various fatty acid-derived compounds such as … See more Expression of PPAR-α is highest in tissues that oxidize fatty acids at a rapid rate. In rodents, highest mRNA expression levels of PPAR-alpha are found in liver and brown adipose tissue, followed by heart and kidney. Lower PPAR-alpha expression levels are found in … See more PPAR-α is the pharmaceutical target of fibrates, a class of drugs used in the treatment of dyslipidemia. Fibrates effectively lower serum triglycerides and raises serum See more PPAR-α has been shown to interact with: • AIP, • EP300 • HSP90AA1, • NCOA1, and See more PPAR-α is a transcription factor regulated by free fatty acids, and is a major regulator of lipid metabolism in the liver. PPAR-alpha is activated … See more Studies using mice lacking functional PPAR-alpha indicate that PPAR-α is essential for induction of peroxisome proliferation by a diverse set of synthetic compounds referred to as peroxisome proliferators. Mice lacking PPAR-alpha also have an … See more PPAR-α governs biological processes by altering the expression of a large number of target genes. Accordingly, the functional role of PPAR-alpha is directly related to the … See more
WebPeroxisome proliferator-activated receptors (PPARs) are fatty acid-activated transcription factors of nuclear hormone receptor superfamily that regulate energy metabolism. Currently, three PPAR subtypes have been identified: PPARα, PPARγ, and PPARβ/δ. PPARα and PPARδ are highly expressed in oxidativ …
WebPeroxisome proliferator-activated receptors: Targets for the treatment of metabolic illnesses (Review) food containers lunch blocksWebOct 13, 2003 · Background— Peroxisome proliferator–activated receptor-α (PPAR-α) is expressed in the heart and regulates genes involved in myocardial fatty acid oxidation … food containers mold trackersWebPeroxisome proliferator-activated receptor α (PPARα) plays a crucial role in the regulation of fatty acid oxidation in the liver. However, the role of PPARα in HCC remains unclear. … elastic modulus of concrete 57000WebMar 21, 2024 · Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors activated by fatty acids to regulate the metabolic processes, with three separate isotypes known as PPARα, PPARγ, and PPARβ/δ (Christofides et al., 2024). food containers for refrigeratorWebIn this study we used lentiviral vector-mediated transfection technology to evaluate the effect of peroxisome proliferator-activated receptor gamma (PPAR-γ) on rat hepatic fibrosis. Methods Hepatic fibrosis in rats was induced by CC14 for 2 weeks (early fibrosis) and 8 weeks (sustained fibrosis). elastic modulus of dentinWebFeb 23, 2024 · The peroxisome proliferator-activated receptor γ (PPARγ) is generally regarded as a molecular target for the thiazolidinedione class of anti-diabetic drugs [ 5, 6 ], as it plays a key role in the generation and development of diabetes mellitus [ 7, 8, 9 ]. food containers microwave safeWebMay 29, 2015 · Pioglitazone, a selective ligand of peroxisome proliferator-activated receptor gamma (PPARγ), is an insulin sensitizer drug that is being used in a number of insulin-resistant conditions, including non-alcoholic fatty liver disease (NAFLD). elastic modulus of delrin