TīmeklisNICD-RBPJ interaction leads to the recruitment of a mastermind-like protein (MAML1–3 in mammals) promoting transcriptional activation. The action of the NOTCH signaling … Tīmeklis2016. gada 12. jūl. · RBPJ binds and trans-activates the Il23r promoter and induces IL-23R expression and represses anti-inflammatory IL-10 production in Th17 …
Specification of CNS macrophage subsets occurs postnatally in
Tīmeklistion of tumor-associated macrophages (TAMs) depends on RBPJ-mediated Notch signaling. In this process, Notch may play both tumor-promoting and tumor-suppressive roles within the same tissues, and this path-way may contribute either negatively or positively to FIG. 1. Notch1-mediated dual regulation of M1 macrophage activation … Tīmeklis2024. gada 6. jūn. · Collectively, we defined a critical role for AGEs in inducing M1 polarization and osteoclastogenesis of macrophages, and further identified Notch/NICD/RBP-J signaling axis as an essential mechanism regulating AGEs-mediated M1 polarization. Introduction the times archive
bioRxiv preprint doi: https://doi.org/10.1101/2024.12.20.473423; …
Tīmeklis2024. gada 8. jūl. · Recombination signal-binding protein Jκ (RBP-J)-mediated Notch signaling regulates macrophage development and phenotype. Here, using bleomycin-induced fibrosis model combined … Tīmeklis2012. gada 20. maijs · (RBPJ-KO) macrophages, using antibodies. against IRF8 (d) and Pol II (e). Occupancy was determined by qPCR amplification over the. promoter region of . Il12b. Data are shown as means + SD of ... TīmeklisMore importantly, in macrophages with targeted deletion of Rbpj, CSL/RBP-Jκ, possibly through canonical Notch signaling, was found to be required for activation of M (IL-4) or M (chitin), including the expression of the gene signature associated with M (IL-4), such as Arg1 expression ( 27 ). setting initial velocity